The problem is that a lot of characters in Scott Pilgrim don't fit with a lot of our characters, especially the male ones. There's no one who's looking into world domination or old mad scientist, the only fit I see is Gideon for being a dick and being a genius and the main bad and one of the Katayanagi twins since they are mechanical geniuses, and both their fights in the agmes are homages to Dr. Wily. But for a maniacal hammy genius I got nothing since both characters are super petty, Gideon especially.
Granted the Katayanagi twins were only seen as petty for me because of what Ramona did to them since she is a [sonic slicer] and Gideon probably messing with their heads. and honestly I have to say Robin, Taylor's creepy villain, fits the twins well.