Looking at the screenshots for that Haydee game, one glaring inaccuracy sticks out.
Breasts don't sit like that in clothing, and if they do it's incredibly uncomfortable. Clothing tends to smoosh them down. Having the clothing formfit and lift them up like that is incredibly unrealistic, and in an environment that that game takes place in it's incredibly impractical.
Also the one-piece type bottom part of it would also be incredibly uncomfortable and unsuited to battle or exploration or anything. You'd have massive chafing no matter what, and it would be quite distracting and painful.
And in general, breasts of that size would be incredibly straining on one's back. The body shape is not quite right to manage to carry breasts of that size, the shoulders should be a bit broader. I mean, you may
think that's realistic proportions but it's really not at all. Take it from someone who actually has breasts and wears clothes in the real world, and not a game that uses "Also a sexy character" as a tagline to sell it.
[spoiler=NSFW-ish GIFs]
Breasts don't work like this, at all, and if one had breasts of that size without the proper body proportions to carry them they would not be able to move that easily or fluidly. Also why do they suddenly elongate in that second GIF when she starts running? Just admit it, you're only into this game and defending it because of this:
[/spoiler]
Oh and Rob Liefeld is never a valid artist to cite as cartoony because his art is bad and he never was going for cartoony, he was going for more realistic and failing.