It must be a popular franchise. Or a franchise long thought dead. Otherwise it wouldn't be "big"
It's either RE or DMC. One of those two at least, if not both.
I wouldn't put it past Capcom to do such a thing, especially since they're on this whole "Westward appeal" kick of theirs. Not to mention Final Fight Streetwise and Street Fighter: The Move: The GAME serve as ever consistent reminders of what happens when Capcom has lapses in judgment like this...
Any way, at this point, the main thing I could stand to see is a new Darkstalkers announced. As much as such a thing tantalizes and worries me all at once, I really want to see a new game made. They give me that, and it's a worthy sequel to Vampire Savior, and I won't even be all that worried about the likes of Donovan and Talbain/Gallon getting into MvC3.
Plus, thus far, the only major Capcom games that have really done anything for me this generation (if the MM 8bit games don't count), are their fighting games. And I say that, even with the thing that I don't particularly care for SF4. That's still a bit more than can be said for the likes of RE5, Lost Planet, Dead Rising, DMC4 and especially Bionic Commando (NOT Rearmed)....