That is not in the least canonical fact. It is a personal statement by Ryuji Higurashi in regards to why he chose to redesign X for Command Mission. And, incidentally, it's also old news, since that quote was already spotted in the japanese version of R20.
Capcom supervised, but did not make, MegaMan Zero; Inticreates did that. Higurashi is involved in Classic, X, and Battle Network, not in Zero. Zero-series was
initially said to take place 100 years after X, or 22XX.
HOWEVER, Inticreates themselves expanded the series gap during the development of Zero-series sequels in order to accommodate the origins of the Dark Elf, creating the Elf Wars which is in itself 100 years prior to Zero-series, and mandating that Zero has to drop out of action for a long time before Elf Wars in addition to being sealed afterwards. For this reason it is exceedingly unlikely for MMZ to take place 100 years after
anything X-series related unless the X-series were to touch on Elf Wars, which Command Mission gave no indication of doing.
On the surface, this seemingly necessitates a 200-year gap between X series and Zero series, although there is some debate on the matter of whether or not Zero's first seal lasted as long as was originally intended, due to MMZOCW referencing only a half-century of Sigma Virus experiments on Zero. Whether or not Zero was subject to such experiments during the entire length of his seal, and at what point if any Weil obtaining Zero's body cut off the intended procedures of his first seal (which was initially estimated at 102 years) is a whole other batch of speculation. Nevertheless, 150 years, bare minimum (200+ still being likely), following Zero's first seal, which there is no reference of in Command Mission. That's when Zero-series takes place.
Zero-series in 22XX is ridiculously outdated information; no way is it true of the completed series without one hell of a forced and convoluted explanation. Command Mission was released in 2004, Z2 in 2003, so Inticreates' reshaping of the series gap had already begun. Higurashi was simply out of the loop on that, because the Zero-series isn't his bag. But that misunderstanding yielded a cool design, so all was good.