Nintendo has to announce something really big for the Wii at E3. the Wii is in a real slump over in Japan; PS3's been beating it for a while. and Punch Out and Wii Sports Resort alone will not fix that. they need a new Zelda or something. Ninty needs to come out with some DSi exclusives, too.
Sony's set with the PS3 in Japan, what with FFXIII supposedly coming out at the end of the year. i say supposedly, cause i can guarantee it will get delayed at least one more time. i'm as sure of that as VersusXIII getting a 360 release. but Sony needs to ante up a little bit for outside Japan. also, those rumors of a PSP 4000 may very well come true at E3.
i don't have anything to say about Microsoft. they have barely any exclusives left. guess Rare fans are going to have to keep holding on to hope of a KI3 announcement. although, there was a rumor about Perfect Dark XBLA, which would be pretty sweet.
as for multiplatform stuff, at this point its going to be hard to top Bayonetta.