Origination: The endocannabinoid system (ECS) is named after the plant which led to its discovery.Significance: It is one of the most vital biological and physiological system used in balancing and maintaining the health of human.
Occurrence: ECS is composed of endocannabinoids and these endocannabinoids have their receptors. They are naturally found throughout the body, mainly in the periphery of the nervous system. They are also available in the brain, connective tissues, organs, immune cells, and glands.
Different Roles Of ECS● ECS As An Internal EquilibratorECS offers different tasks in connecting tissues and brains, but the ultimate goal is to restore the body to the equilibrium condition. The process of restoration is called as homeostasis. It is all about regulating a stable internal environment, no matter the extent of external environment fluctuates.
● ECS As A CoordinatorECS is found at the junction of various components. It acts as a bridge of communication between the different cells and different tissues. The complex actions performed by endocannabinoid system in our nervous system and immune system result in calling it a literal bridge between body and mind. This system is exclusively read to deal with mechanism responsible for the states of consciousness.
● ECS Influence According To The External EnvironmentApart from maintaining and stabilizing the internal environment (homeostasis), the additional job of ECS is to influence a person's relationship with the external environment. But ECS is not capable of influencing the external behavior directly. Some additional substance like cannabinoids is administered to agonize the receptors in the ECS, which result in mood formatting and refreshment.
● ECS As Metabolic ControllerThe ECS has been known to play a homeostatic role by maneuvering metabolic functions. It does by storing energy and transporting the nutrient. It is known to operate on peripheral tissues like the gastrointestinal tract, the skeletal muscles, and the endocrine pancreas. It has also indicated its potency in modulating insulin sensitivity. If these roles are checked at the macroscopic level, they are making a great fit for a cardiovascular role.
HOW ECS Works?The function of ECS is nicely organized. It is carried by three important components:The ReceptorsThe endocannabinoid system (ECS) is a collection of cell receptors and molecules. At
best thc edibles, cell receptors can be compared to the little locks on the cells. The agonists are the chemical keys which unlock these receptors (agonizes). Once the agonizers agonize the receptors, a circuit is completed.
The two primary cell receptors which form the endocannabinoid system i.e., Cannabinoid Receptor 1 (CB1) and Cannabinoid Receptor 2 (CB2). The key which agonizes these locks is called as endocannabinoids.
EndocannabinoidsEndocannabinoids are the natural THC. Breaking down the word, Endo means within, and cannabinoid referring to a compound that fits exactly within the cannabinoid receptors.
Metabolic EnzymesThe third component of the ECS is named as metabolic enzymes. They quickly break down the endocannabinoids once they are used. FAAH AND MAGL are the two enzymes which break down the anandamide and 2-AG (the two main endo molecules) respectively when not in need.
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