If there's one thing I could see them directly llift from the DMC/GoW-genre, it's the way that genre handles "leveling".
In other words, you don't get "level-ups". You instead save up "points" from killing enemies, that you use to buy new abilities, items and such.
It may not be perfect, and I could always stand to see more done to keep it fresh, but it's definitely a much better means to keep things in the game balanced, as opposed to a more traditional, EXP-based system, that the modern CVs used.
Or, of course, they could just say "screw you" that type of dynamic altogether. I certainly wouldn't mind. A more "true-to-form" Metroid way of doing things would be fine by me, where in that you had to earn your power-ups by finding them. And if this game was going to be more like CV2, where you're free to wander about the countryside prior to reaching Drac's turf, so much would be fine in my eyes.