Seriously the game is in 3D, there is going to be at least 100 more Pokemon added to the already massive number of 649, the trainer can be customized, there's Mega Evolutions, there's still a lot of gender differences and new forms, we can ride on Gogoats and Ryhorns, and then there's the online features and finally the Pokebank.
I don't think we have to worry about Memory.